COURSE INSTRUCTORS:
Doina Azoicai, MD, PhD
Epidemiologist, Professor, Department of Public Health and Epidemiology
Coordinator of the Oncogenetics Department
Director of Centre d’Enseignement et de Ressources en Epidémiologie Clinique Iași (CEREC Iași) – RECIF (Réseau d’Epidémiologie Clinique International Francophone)
University of Medicine and Pharmacy “Grigore T.Popa” Iasi
Coordinator of the Department of Prevention of Healthcare Associated Infections.
Institute of Cardiovascular Disease Iasi
doina.azoicai@umfiasi.ro
Raluca Balan, MD, PhD
Pathologist, MD
Associate Professor Department of Morphofunctional Sciences I – Histology
University of Medicine and Pharmacy “Grigore T. Popa” Iasi
Anatomic Pathology Service
Clinical Hospital of Obstetrics and Gynecology “Elena Doamna” Iasi
raluca.balan@umfiasi.ro
Valeriu Aurelian Chirica, PhMD
Epidemiologist
Assistant Professor , Department of Public Health and Epidemiology
University of Medicine and Pharmacy “Grigore T.Popa” Iasi
valeriuchirica@umfiasi.ro
Daniela Druguş
PhD Economist manager
Associate Professor Department of Health Economics University of Medicine and Pharmacy “Grigore T. Popa” Iasi 16, Universitatii Street, Iasi, Romania
Medical Manager “Arcadia” Hospital, 2, Cioarei Street, Iasi, Romania
daniela.drugus@umfiasi.ro
Bogdan Gafton, MD, PhD
Medical Oncologist
Assistant Professor Department of Medical Oncology
University of Medicine and Pharmacy “Grigore T.Popa” Iasi 16, Universitatii Street, Iasi, Romania
Regional Institute of Oncology, Iasi 2-4 General Berthelot Street, Iasi, Romania
gaftonbogdan@umfiasi.ro
Cristina Gavrilovici
Pediatrics and Medical ethics
Professor, MD, PhD “Mother and Child” Department
President of “Grigore T. Popa” University Ethics Committee
University of Medicine and Pharmacy “Grigore T.Popa” Iasi, 16, Universitatii Street, Iasi, Romania
cri.gavrilovici@umfiasi.ro
Eusebiu Vlad Gorduza
Medical Geneticist
Professor Department Medical Genetics
University of Medicine and Pharmacy “Grigore T.Popa” Iasi
Coordinator of the Prenatal Cytogenetics Laboratory
Clinical Hospital of Obstetrics and Gynecology “Cuza Vodă” Iasi
eusebiu.gorduza@umfiasi.ro
Mihaela Grigore
Gynecologist
Professor “Mother and Child” Department
Coordinator of the “Mother and Child” Department
University of Medicine and Pharmacy “Grigore T.Popa” Iasi
Clinical Hospital of Obstetrics and Gynecology “Cuza Vodă” Iasi
mihaela.grigore@umfiasi.ro
Cristian Lupascu
General Surgeon
Professor, Department of Surgery
University of Medicine and Pharmacy “Grigore T.Popa” Iasi 16, Universitatii Str, Iasi, Romania
Emergency County Hospital «Sf. Spiridon» Iasi 1, Independentei Bld, Iasi, Romania
cristian.lupascu@umfiasi.ro
Corina Lupascu-Ursulescu
Radiologist
Associate Professor, Department of Surgery, Discipline of Radiology and Medical Imaging
University of Medicine and Pharmacy “Grigore T. Popa” Iasi; 16, Universitatii Street, Iasi, Romania
Emergency County Hospital “Sf. Spiridon” Iasi 1, Independentei Bld.,Iasi, Romania
corina.ursulescu@umfiasi.ro
Catalina Mihai
Gastroenterologist
Associated Professor Internal Medicine – Gastroenterology Department, University of Medicine and Pharmacy “GrigoreT.Popa” Iasi
Hospital “Sf. Spiridon”, Institute of Gastroenterology and Hepatology, Iasi
catalina.mihai@umfiasi.ro
Mihai Marinca
Medical Oncologist
Assist. Professor, Department Medical Oncology
Lecturer / Senior Consultant
University of Medicine and Pharmacy “Grigore T.Popa” Iasi 16, Universitatii Street, Iasi, Romania
Regional Oncology Institute Iasi 2-4, street Gen. Henri Mathias Berthelot, Iasi, Romania
mihai.marinca@umfiasi.ro
Mioara Calipsoana Matei
Epidemiologist
Associate Professor, Department of Public Health and Epidemiology
University of Medicine and Pharmacy “Grigore T.Popa” Iasi 16, Universitatii Street, Iasi, Romania
Coordinator of the Department of Prevention of Healthcare Associated Infections
Military Emergency Clinical Hospital Iasi 7-9, Berthelot Henri Mathias Street, Iasi, Romania
mioara.matei@umfiasi.ro
Lucian Miron
Medical Oncologist
Professor in Medical Oncology Department
University of Medicine and Pharmacy “Grigore T.Popa” Iasi 16, Universitatii Street, Iasi, Romania
Head of Medical Oncology Department
Oncologic Regional Institute Iasi 2-4 General Berthelot Street, Iasi, Romania
lucian.miron @umfiasi.ro
Aliona Morariu, PhD
Biologist
Biologist at Oncogenetics Department, Iasi
University of Medicine and Pharmacy “Grigore T.Popa” Iasi 16, Universitatii Street, Iasi, Romania
alionamorariuu@yahoo.co.uk
Lucian Negura
Molecular Biologist
Associate Professor, Immunology Department
Responsible of Molecular Oncogenetics Laboratory, UMF Iași
University of Medicine and Pharmacy “Grigore T.Popa” Iași 16, Universității Street, Iași, Romania
lucian.negura@umfiasi.ro
Roxana Postolica
Clinical Psychologist , Psychotherapist
Regional Oncology Institute, Iasi 2-4, Gral Berthelot Street, Iasi, Romania
roxana.postolica@yahoo.com
Cristina Preda
Endocrinologist
Professor Department of the Endocrinology
Coordinator of the Endocrinology Department UMF Iasi
University of Medicine and Pharmacy “GrigoreT.Popa” Iasi 16, Universitatii Street, Iasi, Romania
Emergency County Hospital “Sf. Spiridon” Iasi 1, Independentei Bld.,Iasi, Romania
cristina.preda@umfiasi.ro
Iulian Radu
General Surgeon
Lecturer , Department of Surgery
University of Medicine and Pharmacy “Grigore T. Popa” Iasi 16, Universitatii Street, Iasi, Romania
Head of First Surgical Unit
Regional Institute of Oncology Iasi 2-4 General Berthelot Street, Iasi, Romania
iulian.radu@umfiasi.ro
Gabriela Stefanescu
Gastroenterologist
Associate Professor Internal Medicine – Gastroenterology, Department
University of Medicine and Pharmacy “Grigore T. Popa” Iasi 16, Universitatii Street, Iasi, Romania
Hospital “Sf. Spiridon”, Institute of Gastroenterology and Hepatology, Iasi 1, Bd. Independentei, Iasi, Romania
gabriela.stefanescu@umfiasi.ro
CONTRIBUTORS
| ROMANIA | Florentina NAE
Gabriela TOADER Mădălina – Elena ARGĂSEALĂ Magdalena Maria MICU Irina GHEORGHIU Stefan COLIBABA Doina SPIȚĂ Maria Elza Floarea GHEORGHIU |
| FRANCE | Yves-Jean BIGNON
Mathilde GAY-BELLILE Mathias CAVAILLE Marina GILARDEAU Mathis LEPAGE |
| BULGARIA | Nonka MATEVA
Ivan NOVAKOV Radka MASSALDJIEVA Vili STOYANOVA Hristo IVANOV Jana MLADENOVA |
| HUNGARY | Farkas ANDRÁSNÉ
Zita BORBÉNYI Zsuzsanna LÁSZLÓ Anikó GÁRGYÁN Zsuzsanna HORVÁTH-GÁRGYÁN |
-
Part 1 General elements
The course has 2 sections, part 1 addressed the general elements regarding: descriptive epidemiology of cancers and risk factors; essential clinical elements found in hereditary cancers; elements of human genetics and basic notions in molecular biological diagnosis in monogenic and multifactorial cancers; general aspects regarding the monitoring of hereditary risk in cancer. Instructions: In order to progress, course attendances have to go through every lesson and quiz. The lessons order is fixed (course attendances cannot skip lessons).
- Lesson I.1. Descriptive epidemiology of cancers
- Quiz I.1. Descriptive epidemiology of cancers
- Lesson I.2. Risk factors of cancers
- Quiz I.2. Risk factors for cancers
- Lesson I.3.1. Essential clinical elements in hereditary colorectal cancer
- Quiz I.3.1. Essential clinical elements in hereditary colorectal cancer
- Lesson I.3.2. Essential clinical elements in hereditary breast and ovarian cancer
- Quiz I.3.2. Essential clinical elements in hereditary breast and ovarian cancer
- Lesson I.3.3. Essential clinical elements of hereditary cancer/ endocrine cancers
- Quiz I.3.3. Essential clinical elements of hereditary cancer/ endocrine cancers
- Lesson I.4. Basis of medical genetics: Mendelian genetics, population genetics
- Quiz I.4. The basics of human genetics
- Lesson I.5. The biological and molecular basis of the hereditary monogenic and multifactorial risk of cancer
- Quiz I.5. The biological and molecular basis of the hereditary monogenic and multifactorial risk of cancer
- Lesson I.6. The oncogenetic molecular diagnostic
- Quiz I.6. The oncogenetic molecular diagnostic
- Lesson I.7. The monitoring of individuals with hereditary risk of cancer
- Quiz I.7. The monitoring of individuals with hereditary risk of cancer
- Lesson I.8. Psychological aspects of hereditary cancer – general notions
- Quiz I.8. Psychological aspects of hereditary cancer – general notions
- Lesson I.9. The ethical issues of hereditary cancers
- Quiz I.9. The ethical issues of hereditary cancers
-
Part 2 Oncogenetic monitoring
Part 2 presents the aspects related to oncogenetics monitoring, with knowledge related to: the structure and organization of an Oncogenetics Department; the way and selection criteria of including the patients with hereditary cancer and their family in oncogenic monitoring; solutions for the implementation of molecular diagnostic methods; monitoring of persons at increased risk of hereditary cancer through screening measures; rules of good practice. Instructions: In order to progress, course attendances have to go through every lesson and quiz. The lessons order is fixed (course attendances cannot skip lessons).
- Lesson II.1. The structure and the organization of the Department of Oncogenetics
- Quiz II.1. The structure and the organization of the Department of Oncogenetics
- Lesson II.2. The inclusion of the patients and families in the oncogenetic program. How to use the oncogenetic software
- Quiz II.2. The inclusion of the patients and families in the oncogenetic program. How to use the oncogenetic software
- Lesson II.3.1. The selection criteria. Difficulties and challenges in hereditary colorectal cancer
- Quiz II.3.1. The selection criteria. Difficulties and challenges in hereditary colorectal cancer
- Lesson II.3.2. The selection criteria. Difficulties and challenges in breast and ovarian cancer
- Quiz II.3.2. The selection Criteria. Difficulties and challenges in breast and ovarian cancer
- Lesson II.3.3. The selection criteria. Difficulties and challenges in endocrine tumors
- Quiz II.3.3. The selection criteria. Difficulties and challenges in endocrine tumors
- Lesson II.4. Solutions for the implementation of the molecular diagnostic in the Department of Oncogenetics
- Quiz II.4. Solutions for the implementation of the molecular diagnostic in the Department of Oncogenetics
- Lesson II.5. Interpretation of the molecular diagnosis results: from the laboratory test to the clinical decision
- Quiz II.5. Interpretation of the molecular diagnosis results: from the laboratory test to the clinical decision
- Lesson II.6. The monitoring of people at high risk for cancer: screening, preventive measures. How to ensure the quality of monitoring
- Quiz II.6. The monitoring of people at high risk for cancer: screening, preventive measures. How to ensure the quality of monitoring
- Lesson II.7.1. Good clinical practice in the management of the hereditary risk of breast and ovarian cancer
- Quiz II.7.1. Good clinical practice in the management of the hereditary risk of breast and ovarian cancer
- Lesson II.7.2. Good clinical practice in the management of the hereditary risk of breast cancer
- Quiz II.7.2. Good clinical practice in the management of the hereditary risk of breast cancer
- Lesson II.7.3. Good clinical practice in the management of the hereditary risk of breast cancer
- Quiz II.7.3. Good clinical practice in the management of the hereditary risk of breast cancer.
- Lesson II.8.1. Good clinical practice in the management of hereditary risk of colon cancer
- Quiz II.8.1. Good clinical practice in the management of hereditary risk of colon cancer
- Lesson II.8.2. Good clinical practice in the management of hereditary risk of colon cancer
- Quiz II.8.2. Good clinical practice in the management of hereditary risk of colon cancer
- Lesson II.9. Good clinical practice in the management of endocrine tumors and cancers
- Quiz II.9. Good clinical practice in the management of endocrine tumors and cancers
- Lesson II.10. Good clinical practice in the management of rare ereditary syndromes (like Li Fraumeni)
- Quiz II.10. Good clinical practice in the management of rare ereditary syndromes (like Li Fraumeni)
- Lesson II.11.1. Chances of prophylactic surgery in the personalized oncogenetic monitoring program – Breast and ovarian cancer
- Quiz II.11.1 Chances of prophylactic surgery in the personalized oncogenetic monitoring program – Breast and ovarian cancer
- Lesson II.11.2. Chances of Prophylactic Surgery in the Personalized Oncogenetic Monitoring Program Colorectal cancer
- Quiz II.11.2. Chances of Prophylactic Surgery in the Personalized Oncogenetic Monitoring Program Colorectal cancer
- Lesson II.12.1. Monitoring of patients diagnosed with hereditary cancer and their families
- Quiz II.12.1 Monitoring of patients diagnosed with hereditary cancer and their families
- Lesson II.12.2. Monitoring of patients with hereditary colorectal cancers (adaptation of medical care – personalized medicine)
- Quiz II.12.2. Monitoring of patients with hereditary colorectal cancers (adaptation of medical care – personalized medicine)
- Lesson II.12.3. Monitoring of patients with endocrine hereditary cancers (adaptation of medical care-personalized medicine
- Quiz II.12.3. The monitoring of patients with endocrine disorders hereditary cancers (adaptation of health-personalized medicine)- endocrine disorders
- Lesson II.13. International regulations applicable in oncogenetic department
- Quiz II.13. International regulations applicable in oncogenetic department
- Lesson II.14. Psychological counseling in oncogenetic monitoring
- Quiz II.14. Psychological counseling in oncogenetic monitoring
